The defeats to West Ham and Manchester United in their last two league matches have seen Spurs go two hours and 16 minutes without having a shot on target.
Tottenham have sacked manager Nuno Espirito Santo after four months in charge following a disappointing start to the season.
His coaching staff have also been relieved of their duties, the north London club said in a statement.
The 47-year-old Portuguese manager was only hired in June.
Former Chelsea boss Antonio Conte is being lined up as the next Tottenham manager, according to Sky in Italy.
Talks between Conte and Spurs are said to be at an advanced stage with the Italian, who left Inter Milan in the summer, expected in London today.Advertisement
Spurs’ football managing director Fabio Paratici said: “I know how much Nuno and his coaching staff wanted to succeed and I regret that we have had to take this decision.
“Nuno is a true gentleman and will always be welcome here. We should like to thank him and his coaching staff and wish them well for the future.”
It comes after Spurs went down 3-0 at home to Manchester United on Saturday, leaving them languishing in eighth in the Premier League table.
Tottenham appointed former Wolves manager Nuno as successor to compatriot Jose Mourinho, who like Conte used to manage Chelsea, on 30 June.
His team’s 17 games in all competitions have featured seven defeats, including to arch rivals Arsenal.
The losses to West Ham and Manchester United in their last two league matches have seen them go two hours and 16 minutes without even having a shot on target.
Sunday’s game saw sections of the crowd chant “You don’t know what you’re doing”, and captain Harry Kane was booed.
In a statement on its website, Spurs said “Nuno Espirito Santo and his coaching staff Ian Cathro, Rui Barbosa and Antonio Dias have been relieved of their duties”.
The club added that “a further coaching update will follow in due course”.
The Tottenham Hotspur Supporters’ Trust said it took “no pleasure” in Nuno’s sacking and called on the club to reveal what the “short and long-term plans are”.
“There is growing concern among fans about the direction of travel at Tottenham Hotspur,” the trust added.